Despite rhIL-2 manifesting an opposite reaction on the cell viability and proliferation of A-498 and Caki-1 cell lines and no significant alterations on the ACHN and Caki-2 cell lines, we concluded an effect of IL-2 on the RCC cells, depending on the cell line and on the IL-2 concentration (Figure 5). Here, IL2 is linked to renal cell carcinoma.