However, BDNF exhibited weak negative correlations with these biomarkers (e.g., glutamine–BDNF: ρ = −0.12, p = 0.52; caspase-1–BDNF: ρ = −0.24, p = 0.20), revealing a potential decoupling of neurotrophic support from the other processes in chronic PTSD. This evidence concerns the gene CASP1 and post-traumatic stress disorder.