IFNGR1 and metastatic prostate carcinoma: For instance, LY96 and IFNGR1 were identified as prognostic genes in thyroid cancer (THCA) [9]; LY96 is strongly downregulated in osteosarcoma, where it suppresses cell proliferation, migration, and invasion [10]; and IFNGR1 has been associated with poor prognosis in metastatic prostate cancer [11].