VDR and cancer: Furthermore, it is noteworthy that VDR overexpression in human CRC decreases the expression of β-catenin and facilitates its nuclear exportation to the cytoplasm, subsequently inhibiting Wnt/β-catenin signaling, which leads to reduced lymphoid enhancer-binding factor 1 (LEF1) levels and, consequently, a reduction in the expression of cyclin D1, which is likely to increase cancer cells’ sensitivity to apoptosis [36].