CD4 and colorectal carcinoma: By intersecting these findings, we identified 14 key TME cell types crucial for CRC, including activated B cells, type 1 T helper cells, central memory CD8 T cells, MDSCs, effector memory CD8 T cells, neutrophils, activated CD4 T cells, T follicular helper cells, activated CD8 T cells, CD56dim NK cells, NK T cells, immature B cells, endothelial cells and type 17 T helper cells (Figure 5D).