IGF1 and musculoskeletal system disorder: Given that PRP protein levels might be influenced by circadian rhythms independently of platelet counts, we additionally analyzed five key proteins—PDGF-BB, IGF1, HGF, IL6, and IL10—all of which are essential mediators of immune regulation and play a critical role in tissue regeneration and recovery from musculoskeletal disorders [4,23,24,26].