Marked significant changes (relative mean change [95% CI]) were observed in total ketone bodies (acetoacetate + β-hydroxybutyrate) (+615% [366-999]), fasting insulin (-41.2% [-53.1 to -26.4]) and homeostatic model assessment for insulin resistance (-31.8% [-41.4 to -20.6]), as well as α-hydroxybutyrate (+103% [69.9-142]) and the advanced glycation end-products carboxyethyl-lysine (-46.0% [-53.6 to -37.2]) and carboxymethyl-lysine (-50.9% [-59.8 to -40.1]). The gene discussed is INS; the disease is Insulin resistance.