In terms of mechanism, a study with fucoidan, demonstrated its cytotoxic effect on gastric adenocarcinoma cell cultures by inducing apoptosis, which was mediated by a decrease in the expression of antiapoptotic genes, such as Bcl-2 and Bcl-xL, in addition to activation of caspases [26]. The gene discussed is BCL2; the disease is gastric adenocarcinoma.