In clinical settings, chronic use of BAC-containing eye drops in glaucoma patients resulted in the isolation of S. epidermidis strains with elevated MICs and a higher frequency of the qacC/smr efflux pump gene, particularly among methicillin-resistant isolates, suggesting that selective pressure from long-term BAC exposure may contribute to the persistence of multidrug-resistant phenotypes [32]. This evidence concerns the gene LYPD4 and glaucoma.