For example, proline-rich 15 (PRR15), a crucial gene involved in gastrointestinal neoplasia and colon cancer [24], was markedly induced (over 15-fold), while the tumor necrosis factor interacting protein (TRAIP), a replisome-associated E3 ubiquitin ligase crucial for maintaining genome integrity, was significantly down-abundant. Here, TRAIP is linked to malignant colon neoplasm.