Also, during the acute phase of toxoplasmosis, CD4+ T cells expand less efficiently than CD8+ T cells [35], and infected CD4+ T cells undergo rapid apoptosis through mechanisms such as caspase inhibition and with a consequent lack of antigenic stimulation, resulting in reduced responsiveness and favoring persistence of the protozoan [36,37]. The gene discussed is CD8A; the disease is toxoplasmosis.