Tumor-derived EVs were enriched in proteins associated with vesicular transport and tumorigenesis, including Laminin subunit alpha 5 (LAMA5), Syntenin-1 (SDCBP), and Tenascin (TENA), all of which are implicated in cancer progression, metastasis, and exosome biogenesis. This evidence concerns the gene LAMA5 and neoplasm.