The expanded models such as the University of California San Francisco (UCSF) criteria [20], the alpha-fetoprotein score (AFP-score) [31], and Metroticket 2.0 (MT2.0) model [32] primarily rely on tumor morphology [9,17,18,20], but the newer iterations such as the AFP-score and MT2.0 also incorporate biological surrogate markers such as AFP serum levels [9,18]. This evidence concerns the gene AFP and neoplasm.