In Southern Italy, Capozzo et al. examined 65 FTD patients (22 familial, 43 sporadic) and identified only one novel GRN splice-site mutation, corresponding to a very low overall yield of 1.5% (4.5% among familial cases), with no C9orf72 or MAPT variants detected [26]. The gene discussed is C9orf72; the disease is frontotemporal dementia.