They showed that MCC950, which is a selective small molecule inhibitor of NLRP3, markedly reduced the overall mortality of the NEC mouse model, downregulated proinflammatory cytokine expression (mature IL-1β, IL-6, and TNF-α), and markedly improved the severity of histological damage in the intestines of NEC mice. This evidence concerns the gene IL1B and necrotizing enterocolitis.