NLRP3 and Familial cold urticaria: Uninhibited activation of NLRP3 may be connected to diverse inflammatory diseases in humans, cryopyrin-associated periodic fever syndromes, rare hereditary auto-inflammatory diseases involving familial cold urticaria, Muckle-Wells syndrome, and neonatal-onset multisystem inflammatory disease and sepsis [10,11,12], intestinal inflammation, and ulcerative colitis [13].