Metformin influences myocardial fibrosis not only via direct metabolic effects but also through epigenetic regulation of key miRNAs (e.g., miR-29, miR-133, miR-1) and lncRNAs (e.g., H19, nuclear paraspeckle assembly transcript 1 (NEAT1), metastasis associated lung adenocarcinoma transcript 1 (MALAT1), antisense of IGF2R non-protein coding RNA (AIRN)). The gene discussed is NEAT1; the disease is Myocardial fibrosis.