A key focus has been on the miR-21 and miR-200 family (including miR-200a, miR-200b, miR-200c, miR-429, and miR-141), which play a critical role in controlling several aspects of fibrotic activation such as epithelial-to-mesenchymal transition, TGF-β and PI3K signaling, and ECM deposition, all of which are central to the pathogenesis of myocardial fibrosis. The gene discussed is TGFB1; the disease is Myocardial fibrosis.