Elevated Hepatocyte nuclear factor 4 alpha (HNF4α) then trapped β-catenin at the membrane, lowered TCF reporter constructs for Wnt/β-catenin signaling (TOP/FOP) luciferase output, and reduced the activity of several genes involved in cancer progression (including AXIN2, CCND2, RUNX2, and MMP3). Here, HNF4A is linked to cancer.