Diminished omentin-1 might exacerbate MASLD by worsening insulin resistance and inflammation: low omentin correlates with higher glycemia and HOMA-IR, whereas normal omentin enhances insulin-stimulated glucose uptake via Akt and suppresses macrophage NF-κB activation, thereby mitigating systemic insulin resistance and inflammatory signaling [12,35]. This evidence concerns the gene INS and Insulin resistance.