Standard therapeutic management for patients with obesity, MetS, and CVD includes lifestyle changes (weight reduction, diet, physical activity), pharmacotherapy (statins, angiotensin converting enzyme (ACE) inhibitors, beta-blockers, antidiabetic medications), and interventional treatment for acute myocardial infarction (e.g., coronary angioplasty). Here, ACE is linked to obesity due to melanocortin 4 receptor deficiency.