Therefore, we sought to (1) investigate whether whole blood counts, systemic inflammatory indices (NLR and MLR), serum adiponectin levels, and inflammatory gene expression in VAT (pattern recognition toll-like receptors: TLR2 and TLR4; pro-inflammatory cytokines: IL-1β, IL-6, and TNF-α; anti-inflammatory cytokines: IL-1RA, IL-10, and adiponectin) are altered in GDM compared to in pregnant women with normal glucose tolerance (NGT), and (2) determine correlations between systemic and local VAT inflammation in all, GDM, and NGT women. The gene discussed is TLR4; the disease is gestational diabetes.