Thus, synthetic 3-octylpyridinium salt APS8 (Figure 1) was a potent non-competitive α7 nAChR antagonist which induced apoptosis in non-small cell lung carcinoma (A549, SKMES-1) and HT29 human colon adenocarcinoma cell lines [53,54]. Here, CHRNA7 is linked to non-small cell lung carcinoma.