CHRNA4 and glioblastoma: Thus, α-conotoxins PnIA[L10] and RgIA, antagonists of α7 and α9α10 nAChR subtypes, significantly enhanced cell proliferation of the patient-derived glioblastoma cell lines and model glioblastoma U87MG cells in the presence of nAChR agonists under various culturing conditions [39].