The mechanisms employed to stimulate the immune microenvironment in HCC involve an increased proportion of CD8+ T cells and IFN-γ, IL-12–dependent recruitment of CCR9+ CXCR3+ CD4+ T cells into tumors, and the promotion of apoptosis, the same mechanisms investigated in other neoplasms [65]. The gene discussed is CD8A; the disease is hepatocellular carcinoma.