Indeed, as well described by Wu, X.Q. et al. [62], a higher abundance of A. muciniphila is correlated with a reduced incidence of MASLD-HCC and oral administration of A. muciniphila during anti-PD-1-based therapy in HCC mice which led to maximal tumor suppression, increased T-cell infiltration/activation, while its depletion is consistently associated with a poor outcomes. This evidence concerns the gene PDCD1 and hepatocellular carcinoma.