AFP and neoplasm: High expression of CKAP4 is correlated with several clinicopathological features indicative of tumor progression, including elevated α-fetoprotein (AFP) levels, increased inflammation in adjacent liver tissue, poorer tumor histological grades, higher Ishak fibrosis scores, more advanced tumor-node-metastasis (TNM) stage, intrahepatic metastases, and portal venous invasion [20,25].