RB1 disruption has been further characterized in an independent cohort of lung adenocarcinoma (LuAD) tumors, which identified RB1 alterations in 14% of cases, with intragenic complex rearrangements (ICRs) that entail a restructuring of a segment of DNA within a single gene comprising the majority of RB1-altered tumors (6/7). Here, RB1 is linked to lung adenocarcinoma.