In a bioinformatics analysis performed by Lan T and colleagues, it was observed that HOTAIR expression correlates with drug resistance in TMZ-resistant GBM cell lines, showing data where HOTAIR (acting as a ceRNA) regulates β-catenin and MGMT by sponging miR-214, thus increasing TMZ sensitivity in resistant GBM cells [33]. This evidence concerns the gene HOTAIR and glioblastoma.