FABP4 also fosters lipid metabolic reprogramming in CRC, increasing lipid droplet formation through upregulation of Fatty Acid Synthase (FASN), stearoyl-CoA desaturase (SCD), and acyl-CoA synthetase long-chain family member 1 (ACSL1), and contributing to elevated energy metabolism and glycolysis, marked by higher extracellular acidification rate (ECAR), lactate production, and glucose transporter 1 (Glut1)/lactate dehydrogenase A (LDHA) expression [101,103,104]. Here, FABP4 is linked to colorectal carcinoma.