In conclusion, acute exposure to high-dose AChE inhibitor insecticide was associated with an increased risk of pancreatic cancer, with particularly high relative risks observed among women and individuals with diabetes mellitus These findings, although requiring confirmation in future studies, highlight the need for the development and implementation of structured pancreatic surveillance programs for these high-risk patients, especially those who are women or have diabetes, given the poor prognosis of pancreatic cancer due to late detection. The gene discussed is ACHE; the disease is familial pancreatic carcinoma.