The possible apoptotic pathways for anti-cancer effects of curcumin on cell signal transduction include PI3K, Akt, mTOR, ERK5, AP-1, TGF-β, Wnt, β-catenin, Shh, PAK1, Rac1, STAT3, PPARγ, EBPα, NLRP3 inflammasome, p38MAPK, Nrf2, Notch-1, AMPK, TLR-4, and MyD-88 [35]. Here, SHH is linked to cancer.