In this study, we aim to evaluate the usefulness of serum determination of a series of circulating biomarkers potentially involved in the pathophysiology of cerebral ischemia, such as s100b [31,32], neuron-specific enolase (NSE) [33,34], Vascular Endothelial Growth Factor (VEGF) [35,36], and Intercellular Adhesion Molecule 1 (ICAM-1) [37]. Here, ENO2 is linked to Cerebral ischemia.