PNPLA2 and atherosclerosis: According to recent studies, after high-fat feeding, endothelium-specific ATGL-deficient mice led to lipid accumulation in the vasculature and accelerated the development of atherosclerosis, and ATGL deficiency caused endothelial activation induced by endoplasmic reticulum stress through nuclear factor-κB (NF-κB) signaling [22].