NPPB and chronic obstructive pulmonary disease: In Table 8, univariate and multivariate logistic models indicated that, after adjusting for other risk factors, CRP < 12.25 mg/L versus CRP > 12.25 mg/L and NT-proBNP < 325 pg/mL versus NT-proBNP > 325 pg/mL were independent predictors of either mild/moderate COPD stages (GOLD grades 1 and 2) or severe/very severe stages (GOLD grades 3 and 4).