An 80-year-old male with a complex medical history significant for multiple comorbidities (essential hypertension, type II diabetes mellitus, vascular encephalopathy, prior left hemicolectomy for colorectal cancer, multiple treatments for colonic angiodysplasia, and a recent percutaneous transluminal angioplasty with stent placement in the popliteal artery due to peripheral arterial disease, after which he was started on dual antiplatelet therapy) presented with severe IDA (Hb 5.9 g/dL) in March 2025. This evidence concerns the gene GSTM1 and peripheral arterial disease.