In the context of obesity, adipocytes undergo hypertrophy, which subsequently leads to an increased recruitment of immune cells, such as M1 macrophages, and inflammatory mediators within the tissue, including tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β) [10]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.