Consistent with these studies, we found that the elevated levels of TNF-α, iNOS, and nNOS post-PVD were attenuated by perampanel treatment, suggesting that blocking AMPARs with perampanel attenuates the release of pro-inflammatory mediators from M1-phenotype microglia or activated astrocytes in cerebral ischemia [100]. This evidence concerns the gene TNF and brain ischemia.