Specifically, since perampanel has been shown in normal and rat models of SE to alter the upstream regulators of GluA1 phosphorylation at S831 and S845, including the protein kinases such as Ca2+/CaM-dependent protein kinase II (CaMKII), protein kinase C (PKC), cAMP-dependent protein kinase (PKA3), and protein kinase A (PKA) [44]; therefore, further research is needed to reveal the potential of perampanel as a modulator of these protein kinases during cerebral ischemia. This evidence concerns the gene GRIA1 and brain ischemia.