GRIA1 and Anxiety: It is noteworthy that the restored ratio of p-GluA1-S831 and p-GluA1-S845 may reflect the observed improvement in cognitive and anxiety-like behaviors after perampanel treatment in addition to the elevated maintenance of LTP, since the phosphorylated S831 and S845 residues of GluA1 subunits are known to play a crucial role in LTP and synaptic plasticity [92].