With respect to the active co-infection HTB+ group, a DosR-specific cytolytic response by CD4+ T cells was strongly and positively correlated with the acquisition of PD-1 on CD4+ TM cells (r = 0.8467, p = 0.0036), as well as the Treg frequency (r = 0.7852, p = 0.0115), probably consequent to heightened immune activation and pathogenesis. This evidence concerns the gene CD4 and coinfection.