Our recent systematic review of 21 clinical studies revealed that patients with Ménière’s disease (MD), idiopathic sudden sensorineural hearing loss (ISSHL), and acute low-tone hearing loss (ALHL) exhibit significantly higher serum IgE levels compared to healthy controls, with allergen provocation exacerbating endolymphatic hydrops and auditory symptoms in sensitized individuals [15]. The gene discussed is IGHE; the disease is Menkes disease.