AK3 and breast cancer: In contrast, Jiang et al. (2021) included SDC3 in a seven-gene glycolysis-related signature (PGK1, CACNA1H, IL13RA1, SDC1, AK3, NUP43, SDC3) that predicted poorer prognosis in high-risk breast cancer patients in an analysis of The Cancer Genome Atlas mRNA profiling datasets [46].