A further meta-analysis evaluating markers of bone formation (osteocalcin, bone alkaline phosphatase) and markers of bone resorption (procollagen I N-propeptide-P1NP and C-terminal Telopeptide of Type I Collagen-CTX) in children and adolescents with T1D showed that osteocalcin was significantly lower in youth with T1D, meaning that osteoblast-driven bone formation appears altered, without clear evidence of increased resorption or altered overall turnover [61]. Here, CYP27A1 is linked to type 1 diabetes mellitus.