Converging mechanisms—chronic hyperglycemia, absolute or functional insulin deficiency, AGE–RAGE signaling, low-grade, oxidative stress, and mitochondrial dysfunction—impair satellite cell biology and myogenesis, activate catabolic pathways (FOXO–atrogin-1/MuRF1, UPS), stiffen and remodel the ECM, and blunt bone formation while favoring resorption. The gene discussed is FBXO32; the disease is Hyperglycemia.