PPARD and cancer: Indeed, a comprehensive study interrogated the role of PPAR-δ in the metastatic process in different in vivo models across several cancer types: from tail vein experimental metastasis assays with melanoma, lung carcinoma, and colon cancer cells, to orthotopic spontaneous metastasis assays with pancreatic and breast cancer cells, as well as an intrasplenic experimental metastasis assay with colon cancer cells.