Moreover, the metacluster of CD8+PD-1+CD27+CXCR4− T-cells (MC05) negatively correlated with M2-like CD14+CD163+ monocytes (MC06), while CD8+CD14+ T-cells positively correlated with AICDA+ Bregs and IL-10+ B-regs in HIV-positive pre-NHL individuals. The gene discussed is CD8A; the disease is non-Hodgkin lymphoma.