Significant positive correlations were observed between CD19+AICDA+cMYC+ B-cells and M1-like CD14+cMYC+ monocytes (MC02), as well as between CD8+PD-1+CD27+CXCR4− T-cells (MC05) and CD4+FoxP3+PD-1+CD27+CD28+CXCR4−ICOS+ T-cells (MC08) in HIV-positive pre-NHL cases. Here, CD8A is linked to non-Hodgkin lymphoma.