Collectively, our analysis revealed significantly elevated cMYC+ AICDA+ B-cells, CD8+CD20+ T-cells, CD8+CD14+ T-cells, and M2-like CD14+CD163+ monocytes in HIV-positive pre-NHL cases (cART-naïve) compared to HIV-negative and HIV-positive cART-naïve cases, indicating critical dysregulation in immune cell homeostasis. This evidence concerns the gene CD14 and non-Hodgkin lymphoma.