These included a potentially clonal B-cell population (CD20+CXCR4+CXCR5+cMYC+AICDA+) and a germinal center-like B-cell cluster (CD19−CD20+CXCR4+Bcl-6+PD-L1+cMYC+) circulating in HIV-positive pre-NHL (cART-naïve) individuals [49]. This evidence concerns the gene CXCR4 and non-Hodgkin lymphoma.