Metaclusters elevated in HIV-positive pre-NHL compared to HIV-negative had the following phenotypes: CD8+CD27+CXCR4−PD-1+HLA-DR+ (MC05), CD8+CD20+CXCR4−CCR5+CD11b+HLA-DR+ (MC14), CD8+CXCR4− (MC13), a potential complex of T-cells with CD14+ monocytes (MC10), a potential complex of T-cells with CD163+ monocytes (MC07), and CD8+CD20+CD27+CD28−CXCR4−CCR5+PD-1+CD11b+HLA-DR+ T-cells (MC09) (Supplementary Table S2). The gene discussed is CD8A; the disease is non-Hodgkin lymphoma.