Here, the inhibition of NLRP3 inflammasome activity by transmembrane protein 176B (TMEM176B) facilitated EMT while knockdown of TMEM176B in CT26 murine CRC cells increased the expression of NLRP3 inflammasome proteins and epithelial markers, while reducing the expression of mesenchymal markers [64]. The gene discussed is TMEM176B; the disease is colorectal carcinoma.