SOD1 and amyotrophic lateral sclerosis: In SOD1(G93A) mice, the classical animal model of ALS, which bears a mutation in the superoxide dismutase 1 (SOD1) gene, the effect of A2A AR agonists has been investigated both in the pre-symptomatic and symptomatic stage of the disease (e.g., 4–6 weeks and 12–14 weeks old, respectively).