We addressed this objective by assessing in the DS-exposed luminal breast cancer cells the expression of key regulators of these processes, including B-cell lymphoma-2 (BCL-2)-related protein A1(BCL-2A1), cellular FLICE-inhibitory protein (cFLIP), Beclin1, and heme oxygenase-1 (HO-1). The gene discussed is HMOX1; the disease is breast cancer.