bulgaricus, L. brevis) to mice with early-stage AD resulted in a partial improvement in the functioning of two disturbed mechanisms of neuronal proteostasis: the ubiquitin-proteasome system and autophagy, among others, through the activation of sirtuin-1 (SIRT-1)—a neuroprotective deacetylase enzyme that reduces ROS in the CNS [15]. This evidence concerns the gene SIRT1 and Alzheimer disease.