Another study from 2015 reported that cytoplasmic p27, also known as cyclin dependent kinase inhibitor 1B (CDKN1B), can promote epithelial to mesenchymal transition (EMT) and metastasis via the STAT3-TWIST1 pathway in human mammary epithelial cells, breast cancer, and bladder cancer [23]. This evidence concerns the gene CDKN1B and urinary bladder carcinoma.