SETBP1 and myeloproliferative disorder: Isolated isochromosome 17q, i(17q), accounts for less than 1% of myeloid neoplasms, including AML, MDS, and myeloproliferative neoplasms (MPN), and frequently harbors mutations in SETBP1, ASXL1, SRSF2, and NRAS [9, 10].