A total of 26 children started with HMV because of CCHS due to PHOX2B mutation (n = 19), Rapid-onset Obesity with Hypothalamic dysfunction Hypoventilation and Autonomic Dysregulation (ROHHAD) (n = 3) or an elusive diagnosis (n = 4). Here, PHOX2B is linked to obesity due to melanocortin 4 receptor deficiency.