PSEN1 and Alzheimer disease: Therefore, high secretion of pro-inflammatory cytokines (e.g., IL-6) and deficient clearance of Aβ by PSEN1 E280A ALCs may be critical in exacerbating the etiopathogenesis of FAD, such as the accumulation of Aβ42 in plaques and exacerbated neuroinflammatory processes in AD brains.