SPOP and gastric cancer: To identify mutations that evade SPOP without disrupting activation, we found a T356M-STING mutation in a gastric cancer patient (Catalogue of Somatic Mutations in Cancer database; https://www.sanger.ac.uk/tool/cosmic/) that disrupted SPOP binding (Figure 5, D and E) and reduced SPOP-mediated ubiquitination (Figure 5F), extending STING half-life (Figure 5, G–I).