SPOP loss consistently increased STING protein levels, but not those of cGAS, TBK1, or IRF3, across human melanoma (A2058, HMCB, and MeWo), mouse melanoma (B16), human RCC (A498, 786-o, and UMRC6), mouse RCC (Renca), and HEK293 cells (Figure 3, A–C and F, and Supplemental Figure 2, A–H). This evidence concerns the gene SPOP and renal cell carcinoma.