Similar results were observed in RCC 786-o cells, where SPOP loss augmented STING signaling, increased IFN-β transcription, and upregulated multiple ISGs, including CCL5, CXCL10, OAS1, IFIT1, and IFI44 (Supplemental Figure 1, L–R). The gene discussed is IFIT1; the disease is renal cell carcinoma.