Similar results were observed in RCC 786-o cells, where SPOP loss augmented STING signaling, increased IFN-β transcription, and upregulated multiple ISGs, including CCL5, CXCL10, OAS1, IFIT1, and IFI44 (Supplemental Figure 1, L–R). This evidence concerns the gene IFI44 and renal cell carcinoma.