LRRK2 and Parkinson disease: Although the neuropathological hallmark of PD is typically the presence of LBs enriched in α-syn aggregates, carriers of LRRK2 G2019S mutation often lack these classical inclusions, raising the question of whether LRRK2-PD is driven by shared or divergent mechanisms and whether it can serve as a faithful model of sporadic PD [28,29].