APOE and obstructive sleep apnea syndrome: We found that participants with moderate to severe OSA compared with the non-OSA group had an increased risk of developing CMBs at the end of the 8-year follow-up (RR, 2.91; 95% CI, 1.29-6.58; P = .01) with adjustment for APOE4 genotype (eTable 4 in Supplement 1).